Sometimes the Outlook program needs to be rebooted to address or investigate issue.  Adding a new profile is a quick and easy way to address issues you may be having. This gives you the power to reset Outlook but not your customizations, like signatures, those are restored in a new profile.

Adding a New Profile

1. Open Outlook the program and open the File menu option (top left).
2. Under Account Setttings... select Change Profile.
3. Outlook will shutdown and you need to re-open the Outlook program.
4. Upon startup, Outlook will present the profile selection window.  Under Options, choose New... I further suggest choosing "Prompt for a profile to be used" which will ask which profile to use when opening Outlook each time.
   
5. Once the New... Profile has been named (any name works) and added, Outlook will begin the add account process which addes email accounts to your Outlook profile.
6. After finishing, select the newly added Profile and click OK.
7. Outlook will now begin it's first time startup processes, which will set many settings to default values and begin a new cache of stored information. This is why it's very useful to add a profile when experiencing issues, a new slate (identity to Outlook) is achieved minimizing the number of variables that could be affecting you.